Switching monitoring of emulsified cyclosporine from trough level to 2-hour level in stable liver transplant patients
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منابع مشابه
Switching monitoring of emulsified cyclosporine from trough level to 2-hour level in stable liver transplant patients.
After orthotopic liver transplantation (OLT) many patients use emulsified cyclosporine. Recent data showed that blood levels 2 hours after dosing (C-2) better reflect systemic exposure to the drug (area under the blood concentration time curve) than trough levels (C-0) do. We investigated difference in dosage, creatinine clearance (CrCl), blood pressure (BP), freedom from rejection, and relatio...
متن کاملCyclosporine trough concentration monitoring in liver transplant patients.
Trough blood or plasma concentration measurements of CsA must be carefully interpreted in OLT patients in relation to hepatic function, sample timing, assay specificity, and concurrent drug therapy. The RIA:HPLC ratio of blood or plasma measurements will vary with the patient's liver function, the time of blood sampling in reference to the time of drug administration, the absolute CsA concentra...
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Background & Aims: Hypertension, hyperuricaemia and nephrotoxicity are some common side-effects of Cyclosporine A (CsA) treatment in renal transplant recipients. Previous studies suggest that Calcium Channel Blockers (CCB) can increase serum level of CsA and may improve graft function in patients receiving CsA. The aim of this study was to evaluate the effects of Diltiazem and Amlodipine on cyc...
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In this retrospective study, cyclosporine levels at the second hour (C2 levels) were measured during oral cyclosporine intake in 28 pediatric hematopoietic stem cell transplant patients, and the relations between cyclosporine dosage and C0, C2 levels, C2/C0 ratio, and cyclosporine-related adverse effects were investigated. Cyclosporine levels at the second hour levels were found to be significa...
متن کاملCyclosporine Monitoring and Pharmacokinetics in Pediatrie Liver Transplant Patients.
THE DEVELOPMENT of cyclosporine (CyA) as a novel immunosuppressive agent has dramatically advanced orthotopic liver transplantation (OLT). The use of CyA in pediatric OLT patients has been hindered by a lack of information concerning the drug's pharmacokinetics in children and the interpretation of blood concentrations during therapy. OL T should have a major effect on CyA's absorption, distrib...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2004
ISSN: 1527-6465
DOI: 10.1002/lt.20056